Quote
by Dr. Ronald Klatz, President of the American Academy of Anti-Aging Medicine ”The
Ultimate Anti-aging Therapy"
"Growth
Hormone(HGH) affects almost every cell in the body; rejuvenating the skin
and bones, regenerating the heart, liver, lungs and kidneys, bringing
organ and tissue function back to youthful levels". "The rejuvenating
effects of Growth Hormone are global, acting on both mind and body, anatomy
and physiology, form and function" stated by Dr. Ronald Klatz, president
of the American Academy of Anti-Aging Medicine, in his book Grow Young
with HGH.
History
of HGH
Prior to the advent of recombinant DNA technology, the only source of
growth hormone was from human cadavers. More than 27,000 children world
wide were treated with growth hormone of this source. Due to short supply,
children were treated with low doses and interrupted regimens. As a result,
their response and ultimate height was mitigated. Distribution of pit-hGH
was stopped in the United States and most of Europe from infected cattle.
It is impossible to catch Creutzfeldt-Jakob Disease or any other infection
from recombinant human growth hormone because it is not derived from a
human or animal source but from a purified tissue culture. For purposes
of this discussion, the term growth hormone, GH or hGH will mean growth
hormone made by recombinant DNA technology.
The
bio-potency of commercially available growth hormone is typically represented
by either milligrams or units. To put it simply, 1 milligram of growth
hormone is equivalent to 3 units. The international units were developed
by the World Health Organization in order to standardize growth hormone
preparations because of the various production techniques used early on
in the manufacturing process. By now, the manufacturing process has been
streamlined and largely perfected so the bio-equivalency of the various
brands of growth hormone (at least those manufactured and approved by
the FDA for sale in the United States are identical. Therefore, a typical
15-unit vial of growth hormone contains 5 mg and a 4-unit vial contains
1.33 mg.
History
of HGH Research
1920’s,
Scientists have known the existence of Human Growth Hormone.
1958,
Scientists began to apply HGH on children that suffer from dwarfism to
help them grow normally. The effects were very obvious. The theory behind
the use of HGH in those days was that the pituitary gland, which secretes
HGH, was either defective or not functioning at all in those children
with dwarfism. The main source of HGH for treatment at that time was extracted
from the pituitary gland of dead people in Africa. It often took thousand
of brains of the dead to produce just a few drops of HGH! Scientists were,
therefore, forced to research alternatives such as synthetic HGH.
1985,
Genentech succeeded in producing large quantities of HGH through microbiological.
1986,
Eli Lilly was able to produce HGH with 191 amino acids by using bio-engineering
of the genes.
1990,
Dr. Daniel Rudman published another article in the New England Journal
of Medicine that shocked the entire medical fields. This article became
a milestone in anti-aging treatment with the clinical trials of HGH. He
selected 12 males, aged from 61 to 81 for treatment. After 6 months use
of HGH, their fat was reduced by 14.4%; skin thickness increased 7.11%;
bone density increased 1.6%; liver improved 19% and spleen improved 17%.
Dr. Rudman concluded that these 12 old men had become younger by 20 years
both physically and psychologically.
1992,
Encouraged by Dr. Rudman’s HGH theory, the National Institute on
Aging carried out nine clinical experiments that took 5 years to complete.
The results, unprecedented and far-reaching in influence, proved once
again that Dr. Rudman’s theory was correct.
1996,
Dr. Rudman had over 800 HGH patients, including movie stars, corporate
executives, other renowned doctors, specialists and scholars. In his medical
reports, he indicated that among thousands of patients, there was not
even one single case of failure.
Within
the past ten years, there were more than 30,000 case reports, the results
were very encouraging.
1996,
FDA finally approved the usage of HGH in the treatment of both children
and adults for suffering from growth hormone deficiency. It is now recognized
the medical fields that HGH is the major hormone among all hormones. It
guides and promotes the release and secretion of other hormones.
Growth
hormone was initially used for children of short stature who are growth
hormone deficient, either because of an inactive pituitary, a tumor of
the pituitary, or destruction of the pituitary by surgery or radiation
to remove a tumor. The other pituitary hormones were replaced along with
GH. Growth hormone was used only until the children reached an acceptable
adult height and then it was stopped because it was thought to be useful
only for growth. The other pituitary hormones, however, which were thought
to be more critical, were continued through adulthood. It wasn’t
until much later that adult growth hormone deficiency was recognized to
be a problem. It was discovered that adults who were deficient in growth
hormone suffered from premature cardiovascular disease, depressed mood,
elevated levels of LDL (bad) cholesterol, slower wound healing, fatigue,
poor exercise tolerance and poor immune function. At that point the uses
of growth hormone began in this unfortunate population, resulting in improvement
of all of the above. It wasn’t until 1990, however, that the benefits
of growth hormone and the treatment of normal aging were recognized. The
most recent new use of growth hormone is for the treatment of AIDS Wasting
Syndrome. This is the condition of weakness, fatigue, and loss of muscle
mass in AIDS patients.
Human
Growth Hormone (HGH)
Information and Key Findings
Human
growth hormone was first discovered in 1956 and its structure was identified
in 1972. Before synthetic HGH molecules were genetically engineered in
1998, HGH was extracted from cadavers and then injected with needles into
the human body.
Over
the past 3 decades, there have been a growing number of clinical research
studies investigating the capabilities and purported benefits of the human
growth hormone.
Many
researchers have concluded that one of the primary causes of aging is
the decrease of HGH human growth hormone production.
According
to Dr. Ronald Klatz, M.D., President of the American Academy of Anti-Aging
Medicine, “Aging appears to be due in large part to the drastic
decline of growth hormone in the body after adulthood.”
According
to HGH human growth hormone research, at age 21, the normal level of circulating
HGH is about 10 milligrams per deciliter of blood, but at age 61, it’s
decreased 80% to only 2 milligrams. It is believed that growth hormone
is what grows the cells, bones, muscles and organs, and it is the level
of growth hormone after age 30 that slowly robs us of our youth. After
age 30, the secretion rate of HGH drops approximately 14% per decade.
By 80, most people barely produce enough HGH to build a fingernail, explaining
why injuries experienced by seniors take so long to heal.
Human
Growth Hormone (HGH) Research- Clinical Studies
The New England Journal of Medicine published the clinical findings of
Daniel Rudman, MD, regarding his HGH human growth hormone research on
the anti-aging effects of HGH. His findings were astonishing.
Dr.
Rudman studied patients age 61 to 81 at the Medical college of Wisconsin-Milwaukee.
After six months, Dr. Rudman observed a reversal of the aging process
from 10 to 20 years in the patients who received HGH injections. But in
the control group (those who didn’t receive HGH injections), the
normal aging process continued.
Human
Growth Hormone (HGH)
Clinical Research Conclusions
“The
effects of six months of human growth hormone on lean body mass and adipose-tissue
were equivalent in magnitude to the changes incurred during 10-20 years
of aging.”
Daniel Rudman, M.D., New England Journal of Medicine.”
“It
is possible that chronic physiologic GH and/or IGF-I replacement therapy
might reverse (or prevent) some of these “inevitable” sequelae
of aging.” (Study of GH therapy in the elderly-March 1992.)
V.A. Medical Center and Department of Medicine, Stanford University
Medical Center.
“Replacement
therapy with Growth Hormone has shown beneficial/normalizing effect on
parameters such as cardiac and renal function, thyroid hormone metabolism,
bone metabolism, sweat secretion, total and regional fuel metabolism and
psychological well being…”
Dr. Jorgensen and Dr. Christian of Copenhagen, Denmark, in European
Journal of Endocrinology, 1994.
“We
really have something here which may be able to reverse some of the problems
associated with aging.”
Dr. Anthony Karpos, M.D.
“Daily
Administration of human growth hormone in the first week after trauma
would enhance the metabolic status resulting in reduced morbidity and
earlier discharge from hospital.” (May 1992, Journal of Surgery.
Vol 111, 495-502)
Dr. Ramias, Shamos, and Schiller of St. Joseph Hospital Medical Center
in Phoenix, AZ
“All
adults with growth hormone deficiency should now be considered for growth
hormone replacement.” (1995)
Dr. Jake Powrie, M.D. and Dr. Andrew Weissberger, St. Thomas, London
England
“There
is no evidence suggesting that Growth Hormone Replacement Therapy causes
any unfavorable long term side effects.” (Hormone Research, 1995)
Dr. Rosen, M.D. and Dr. G. Johannsson, M.D. of University Hospital,
Goteborg, Sweden.
References
Cited:
1.
Salomon F, Cuneo RC, Hsp R et al. The Effects of Treatment with Recombinant
Human Growth Hormone on Body Composition and Metabolism in Adults with
Growth Hormone Deficiency. New England Journal of Medicine 1989; 321:
1797-1803.
2. Bengtsson BA. The Consequences of Growth Hormone Deficiency in Adults
Acta Endocrinologica 1993; 128 (Suppl 2): 2-5.
3. Cuneo RC, Salomon F, Wiles CM et al. Growth Hormone Treatment in Growth
Hormone Deficient Adults. II. Effects on Exercise Performance. Journal
of Applied Physiology 1991; 70:695-700.
4. O’Halloran DJ, Tsatsoulis A, Whitehouse RW et al. Increased Bone
Density after Recombinant Human Growth Hormone (GH) Therapy in Adults
with Isolated GH Deficiency. Journal of Clinical Endocrinology and Metabolism
1993;76:1344-1348.
5. McGauley GA, Cuneo RC, Salomon F et al. Psychological Well-Being Before
and After Growth Hormone Treatment in Adults with Growth Hormone Deficiency.
Hormone Research 1990; 33 (suppl 4): 52-54.
6. Bengtsson BA, Eden S. Lonn L et al. Treatment of Adults with Growth
Hormone (GH) Deficiency with Recombinant Human GH. Journal of Clinical
Endocrinology and Metabolism 1993; 76; 309-317.
7. Johnston DG, Bengtsson BA. Workshop Report; the Effects of Growth Hormone
and Growth Hormone Deficiency on Lipids and the Cardiovascular System.
Acta Endocrinologica 1993; 128 (Suppl 2); 69-70.
8. Amato G, Carella C, Fazio S. et al. Body Composition, Bone Metabolism,
and Heart Structure and Function in Growth Hormone (GH)- Deficient Adults
before and after GH replacement therapy at low doses, Journal of Clinical
Endocrinology and Metabolism 1993;77: 1671-1676.
9. Stanford University Medical Center (Psycho-Neuro Endocrinology, Vol.
1 no. 4, 1992.
These
statements have not been evaluated by the Food and Drug Administration,
and individual results may vary. This product should be taken as part
of a healthy lifestyle and is not intended to diagnose, treat, cure or
prevent any disease. Consult your physician before using this product,
especially if you have a serious medical condition or are taking prescription
medications.
Life
Improvements
Growth hormone was initially used for children of short
stature who are growth hormone deficient, either because of an inactive
pituitary, a tumor of the pituitary, or destruction of the pituitary by
surgery or by radiation to remove a tumor. The other pituitary hormones
were replaced along with GH. Growth hormone was used only until the children
reached an acceptable adult height and then it was stopped because it
was thought to be useful only for growth. The other pituitary hormones,
however, which were thought to be more critical, were continued throughout
adulthood. It wasn’t until much later that adult growth hormone
deficiency was recognized to be a problem. It was discovered that adults
who were deficient in growth hormone suffered from premature cardiovascular
depressed mood, reduced bone density, central obesity, decreased muscle
mass, depressed mood, elevated levels of LDL (bad) cholesterol, slower
wound healing fatigue, poor exercise tolerance and poor immune function.
At that point the uses improvement of all of the above. It wasn’t
until 1990, however, that the benefits of growth hormone and the treatment
of normal aging were recognized. The most recent new use of growth hormone
is for the treatment of AIDS Wasting Syndrome. This is the condition of
weakness, fatigue, and loss of muscle mass in AIDS patients.
April
2002 (Hypopituitary Control and Complications Study International
Advisory Board (an organization studying the efficacy and safety of HGH
therapy of adult HGH-deficient patients in clinical practice) Dr. Attanasio
and colleagues reported on a three- year course of HGH therapy administered
to adult onset HGH-deficient patients. Lean body mass increase was found
to be greater in those younger than 40 years old, less but still significant
in the middle and older age groups. The researchers submit that “this
observational data showed significant long-term efficacy of adult HGH
replacement therapy on body composition and lipid profiles and indicate
that age is imports predictor of response.”
(Attanasio
AF. Bates PC, Ho KK, Webb SM, Ross RJ, Strasburger CJ, Bouillon R. Crowe
B. Seland K. Valle D, Lamerts SW; The Hypopituitary Control and Complications
Study International Advisory Board Human growth hormone replacement in
adult hypopituitary patients; long-term effects on body composition and
lipid status—3 year results from the HypoCCS Database. J Clin Endocrinol
Metab. 2002 Ar;87(4):1600-6)
November
2001 (KIGS/KIMS Outcomes Research, Pharmacia AB, Stockholm, Sweden):
Data concerning visits to the doctor, number of days in hospital, and
amount of sick leave were obtained from patients included in KIM’s
(Pharmacia International Metabolic Database), a large pharmacoepidemiolgical
survey of hypopituitary adults with GH deficiency ,. Of the 304 patients
surveyed, visits to the doctor, number of days in hospital and amount
of sick leave decreased significantly only for the men. After 12 months
of GH treatment, Quality of Life (assessed by the Qol-Assessment of GHD
in Adults questionnaire) improved, as did both the amount of physical
activity. Dr. Hernberg and colleagues thus conclude that “GH replacement
therapy, in previously untreated adults with growth hormone deficiency,
produces significant decreases in the use of healthcare resources, which
are correlated with improvements in quality of life.”
(Hernberg-Stahl
E, Luger A, Abs, Bengtsson BA, Feldt-Rasmussen U. Wilton P, Westberg B,
Monson JP; KIMS International Board, KIMS Study Group, Pharmacia International
Metabolic Database, “Healthcare consumption decreases in parallel
with improvements in quality of life during GH replacement in hypopituitary
adults with GH deficiency,” J Clin Endocrinol Metab. 2001 Nov:86
(11);5277-81)
October
2001 (University Hospital, Uppsala, Sweden): Dr. Gillberg and
team found that three months of low-dose HGH on 64 HGH-deficient adults
increases serum levels of insulin-like growth factor (IGF)-I, IGF binding
protein (IGFBP)-3 and lipoprotein (a), reduced total and low density lipoprotein
cholesterol levels, and resulted with greater lean body mass and decreased
fat mass. The researchers suggest, “This fixed low-dose regime resulted
in improvements in body composition and lipid profile, without causing
serious side effects. This is therefore a valid method to institute HGH
replacement in adults.”
(Gillberg
P. Bramnert M, Thoren M, Werner S, Johannsson G, “Commencing growth
hormone replacement in adults with a fixed low dose. Effects on serum
lipoproteins, glucose metabolism, body composition, and cardiovascular
function, “Growth Horm IGF Res. 2001 Oct;11 (5): 273-81)
September
2001 (Universitat Munchen, Munich, Germany): Dr. Herschbach and
colleagues from the Institut und Poliklinik fur Psychosomatische Medizin
found scores across numerous psychometricmarkers improved progressively
in adults administered HGH replacement therapy.
(Herschback
P, Henrich G, Strasburger CJ, Feldmeier H, Marin F, Attanasio AM, Blum
WF. Development and psychometric properties of a disease-specific quality
of life questionnaire for adult patients with growth hormone deficiency.
Eur J Endocrinol. 2001 Sep; 145 (3):255-65.)
The
Miracles of HGH
The
revolutionary anti-aging Human Growth Hormone (HGH) discoveries that are
changing the future of medicine. It was the shot heard around the world.
On July 5,1990, the prestigious New England Journal of Medicine published
a medical study on an agent that sent shock waves through the medical
industry.
September
2001 (Universitat Munchen, Munich Germany): Dr. Herschbach and
colleagues from the Institut and Poliklinik fur Psychosomatische Medizin
found scores across numerous psychometric markers improved progressively
in adults administered with HGH replacement therapy.
(Herschbach
P, Henrich G. Strasbuger CJ, Feldmeier H, Marin F, Attanasio AM, Blum
WF. Development and psychometric properties of a disease-specific quality
of life questionnaire for adult patients with growth hormone deficiency.
Eur J Endo9crinol, 2001 Sep; 145(3)255-65
June 2001 (Royal Liverpool University Hospital, United
Kingdom): Dr. Ahmad and team found that weight based HGH replacement resulted
in significant improvements in both body composition and quality of life
as early as one month after the initiation of treatment, and persisted
at three months. Noting that “most importantly, these changes occur
in the absence of side-effects.” The researchers “therefore
suggest the use of low-dose HGH therapy, maintaining IGF-I between the
median and up end of age-related reference range, for the treatment of
adult growth hormone deficiency.”
Ahmad
AM, Hopkins MT, Thomas J, Ibrahim H, Fraser WD, Vora JP. Body composition
and quality life in adults with growth hormone deficiency; effects of
low-dose growth hormone replacement. GLinical Endocrionol (Oxf). 2001
June;54(6):709-17.)
It is the position of the A4M that adult HGH replacement therapy is safe
and effective when administered judiciously by qualified endocrinologist
or anti-aging physician. Of all of the hormones in-use for adult replacement,
HGH has the most extensive history of rigorous scientific practical application.
Growth
Hormone may ease Crohn’s Disease
Crohn’s
Disease, a disorder of the digestive tract causing persistent diarrhea
abdominal pain, bleeding and breakdown of the intestinal wall, has no
known cure, though drugs can ease symptoms in some patients. The cause
of Crohn’s is unknown, but one theory is that infections or hereditary
facts weaken the intestinal wall, making it more susceptible to inflammation
and tissue breakdown when it comes in contact with disease-causing organisms.
An exaggerated immune response may also play a role.
Dr.
Alfred Slonim of North Shore University Hospital in Manhasset, N.Y. and
colleagues based their research on previous studies indicating that growth
hormone improved intestinal repair in patients who had part of their bowels
surgically removed. Slonim theorized that growth hormone may rebuild and
strengthen the intestinal wall. A high-protein diet provides the building
blocks for tissue repair.
In
his study, Slonim found that in 19 adults treated with growth hormone
while a high-protein diet, 11 went into remission. Of the 14 patients
who improved, virtually all said their abdominal pain disappeared. They
also reported less diarrhea. Side effects were mild. Of the 19 in the
study, an additional three others saw significant improvement.
As
a control, eighteen patients took a dummy drug while on a high-protein
diet none reported any changes to their digestive habits. Growth hormone
appeared almost as effective as the anti-inflammatory drug infliximab,
the only medications approved specifically for Crohn’s disease.
Slonim’s study, however, did not perform exams to see whether the
intestinal tissue was healthier.
Source/Reference:
New England Journal of Medicine, June 1, 2000
Studies
Several studies have demonstrated the effects of human growth hormone
(hgh) and elevating insulin growth factor-1 (IGF-1), improving healing
time, decreasing total body fat, increased lean muscle mass, improved
cholesterol and several other effects just to name a few: The role of
hGH on growth, IGF-1 and metabolism effects have been well documents.
Bookshelves are buckling from the weight of studies on hGH and aging.
Many of these studies revealed that hGH injections over periods of three
to eleven months resulted in a feeling of well being with the subsequent
compositional changes and therapeutic benefits. Sometimes referred to
as the “Master Hormone.” hGH or somatotropin is a protein
of about 191 amino acids synthesized in the interior pituitary gland HGH
is the most abundant hormone produced by the pituitary gland. It’s
production peaks during the rapid growth of adolescence, declining with
age.
Turning
Back the Clock
Is aging Inevitable?
“The
overall deterioration that comes with growing old is not inevitable. We
now realize that some aspects of it can be prevented or reversed.”
– Dr. Daniel Rudman
“The
foundation of youth lies within cells of each of us. All you need to do
is release it.” -Dr. Ronald Klatz
Perioperative
Growth Hormone Treatment Increases Nitrogen and Fluid Balance and results
in short-term and long-term conservation of lean tissue.
The
surgical procedure for forming an ileoanal anastomosis with a J pouch
usually involves a temporary ileostomy. Patients undergoing IAA surgery
thus need to recover quickly because they return for ileostomy closure
three months later. We evaluated the effects of perioperative biosynthetic
growth hormone treatment of short and long term changes in body composition
and on nutrition intake. Patients with ulcerative colitis undergoing IAA
surgery were randomly assigned to double-blind treatment with placebo
(n=12) or 6 IU GH twice daily (n=12) from two days before to seven days
after the operation. Examinations were from two days before to nine days
after the operation and on days 30 and 90. Body composition was assessed
with a dual-energy X-ray absorptiometry scanner. The two groups had similar
nutritional intakes. On postoperative day seven, placebo-treated patients
had lost 4.2 kg (95% CI; 3.0, 5.4 ) total tissue mass, 3.6 kg (2.1, 5.1)
lean tissue mass, and 0.5 kg (-0.1, 1.2) fat mass. These reductions persisted
three months later. Compared with placebo, GH improved nitrogen balance,
changes in lean tissue mass (gain of 3.2 kg (1.6, 4.9), P=0.001 but increased
the loss of fat mass (loss of 0.7 kg (0.0, 1.5), P=0.049) on postoperative
day seven. Three months later, the placebo-treated patients had lost 2.4
kg (0.7, 4.2) more lean tissue mass than GH-treated patients (P=0.009
whereas changes in total tissue and fat mass were not significantly different.
Hence, GH treatment enhanced the long-term regain of tissue mass.
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Bones that are less strong